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Journal of Clinical Endocrinology & Metabolism, Vol 52, 1257-1259, Copyright © 1981 by Endocrine Society

ARTICLES

Induction of ovulation in a true hermaphrodite with male phenotype

G Perez-Palacios, A Carnevale, N Escobar, G Villareal, C Fernandez and M Medina

Ovulation was induced in a 16-yr-old 46 XX/47 XXY true hermaphrodite with a male phenotype. The presence of testicular tissue was assessed by a normal androgen response to hCG. Administration of FSH and LH for 8 consecutive days, followed by a single dose of hCG, induced a biphasic serum profile of 17 beta-estradiol and progesterone similar to that observed in normal menstrual cycles. In addition, a significant rise in serum testosterone was noticed during the luteal phase. Laparotomy revealed the presence of a uterus, with evidence of endometrial bleeding and absence of a vagina. These results demonstrated that gonadotropins were able to induce follicular maturation, ovulation, and endometrial bleeding in a true hermaphrodite resembling a normal ovulatory cycle. Gonadotropin administration can be used as a diagnostic tool for establishing the presence of ovarian tissue in this gonadal development abnormality.




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Copyright © 1981 by The Endocrine Society