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Journal of Clinical Endocrinology & Metabolism, Vol 52, 1053-1056, Copyright © 1981 by Endocrine Society

ARTICLES

Effect of N-terminal portion of pro-opiomelanocortin on aldosterone release by human adrenal adenoma in vitro

M Lis, P Hamet, J Gutkowska, G Maurice, NG Seidah, N Lariviere, M Chretien and J Genest

An adrenal cortex adenoma, surgically removed from a female patient with primary aldosteronism, was used to examine the effect of ACTH, angiotensin II, gamma 3-MSH, and the N-terminal fragment of pro- opiomelanocortin purified from porcine anterior pituitaries on aldosterone release in vitro. Primary cultures of tumor cells were incubated as a monolayer in a 96-well microtitration plate and the aldosterone release was measured in the incubation medium after 2 h of incubation in the presence of absence of different concentrations of the peptides. On a molar basis, the N-terminal portion of pro- opiomelanocortin seems to have the highest activity of all of the peptides assayed.




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Copyright © 1981 by The Endocrine Society