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Journal of Clinical Endocrinology & Metabolism, Vol 52, 934-936, Copyright © 1981 by Endocrine Society

ARTICLES

Simultaneous pulsatile release of prolactin and luteinizing hormone induced by luteinizing hormone-releasing factor agonist

RF Casper and SS Yen

Subcutaneous injection of 50 microgram long acting agonist of LRF (LRF- Ag) resulted in the prompt, simultaneous pulsatile release of both LH and PRL in four hypogonadal women. After repeated daily administration of LRF-Ag. LH release in response to LRF-Ag was markedly attenuated, and LH pulses were abolished. LRF-Ag induced PRL release was also attenuated but remained pulsatile. These findings demonstrate the dissociation of the LRF-Ag-induced contemporaneous release of LH and PRL and suggest a hypothalamic site of action of LRF-Ag on PRL release.


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M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy
Prolactin: Structure, Function, and Regulation of Secretion
Physiol Rev, October 1, 2000; 80(4): 1523 - 1631.
[Abstract] [Full Text] [PDF]


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