help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pontiroli, A. E.
Right arrow Articles by Pozza, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pontiroli, A. E.
Right arrow Articles by Pozza, G.

Journal of Clinical Endocrinology & Metabolism, Vol 52, 924-928, Copyright © 1981 by Endocrine Society

ARTICLES

The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress

AE Pontiroli, E De Castro e Silva, F Mazzoleni, M Alberetto, G Baio, G Pellicciotta, A De Pasqua, L Stella, AM Girardi and G Pozza

The present experiments were performed to investigate the possible role of histamine and its receptors, H1 and H2, in the control of PRL and LH release in normal adult humans of both sexes. Histamine infusion (200 microgram, iv, in 15 min) induced PRL and LH release in men; in women, histamine inhibited LH release without affecting PRL release. Two H1 antagonists, dexchlorpheniramine (10 mg, iv) and promethazine (50 mg, im), reduced PRL release in both sexes, stimulated LH release in men, and inhibited LH release in women. Cimetidine, an H2 antagonist (400 mg, iv), elicited PRL release in both sexes, more consistently in females than in males, and was without effect on LH release in either sex. These data suggest that in humans, the effect of histamine on PRL release is linked to H1 and H2 receptors, which respectively stimulate and inhibit PRL release independently of sex. The effect of histamine on LH release appears to depend on sex and to be mediated only by H1 receptors. To rule out the possibility that the effects of histamine are merely due to a nonspecific stress reaction, we have evaluated PRL and LH release in otherwise normal men and women undergoing surgery for gallstones. Surgery was accompanied by PRL release in both sexes, more evident in women, and by LH release only in men. These results indicate that the effect of histamine on PRL and LH release in humans is linked to sex and H1 and H2 receptors and is not due to stress; further studies are required to clarify the possible mechanism and site of action of histamine in modifying PRL and LH release in humans.


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
R. C. Zimmermann, L. E. Krahn, G. G. Klee, E. C. Ditkoff, S. J. Ory, and M. V. Sauer
Prolonged Inhibition of Presynaptic Catecholamine Synthesis With {alpha}-Methyl-Para-Tyrosine Attenuates the Circadian Rhythm of Human TSH Secretion
Reproductive Sciences, May 1, 2001; 8(3): 174 - 178.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
Cs. Fekete, P. H. Strutton, F. R. A. Cagampang, E. Hrabovszky, I. Kalló, P. J. Shughrue, E. Dobó, E. Mihály, L. Baranyi, H. Okada, et al.
Estrogen Receptor Immunoreactivity Is Present in the Majority of Central Histaminergic Neurons: Evidence for a New Neuroendocrine Pathway Associated with Luteinizing Hormone-Releasing Hormone-Synthesizing Neurons in Rats and Humans
Endocrinology, September 1, 1999; 140(9): 4335 - 4341.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society