help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Carr, B. R.
Right arrow Articles by Simpson, E. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carr, B. R.
Right arrow Articles by Simpson, E. R.

Journal of Clinical Endocrinology & Metabolism, Vol 52, 875-881, Copyright © 1981 by Endocrine Society

ARTICLES

Plasma lipoprotein regulation of progesterone biosynthesis by human corpus luteum tissue in organ culture

BR Carr, RK Sadler, DB Rochelle, MA Stalmach, PC MacDonald and ER Simpson

The role of plasma lipoproteins in supplying cholesterol for progesterone biosynthesis by human corpus luteum tissue in culture was investigated. Progesterone secretion by tissue fragments maintained in organ culture reached a maximum rate by the third day and subsequently declined. Maximal secretion of progesterone was dependent on the presence of both low density lipoprotein (LDL) and hCG in the culture medium, whereas high density lipoprotein (HDL) was ineffective in supporting progesterone biosynthesis. Human corpus luteum tissue degraded [125I]iodo-LDL by a mechanism which was saturable, and degradation of [125I]iodo-LDL was stimulated by hCG. Although 3-hydroxy- 3-methylglutaryl coenzyme A reductase activity was present in microsomes prepared from fresh human corpus luteum tissue, the activity of this enzyme in microsomes prepared from tissue maintained in culture for 3 days was virtually undetectable. Fresh human corpus luteum tissue contained 3 times more unesterified cholesterol than esterified cholesterol. It is concluded that LDL, but not HDL, is the major source of cholesterol used by the human corpus luteum for progesterone biosynthesis.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
C. Stocco, C. Telleria, and G. Gibori
The Molecular Control of Corpus Luteum Formation, Function, and Regression
Endocr. Rev., February 1, 2007; 28(1): 117 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M. A. Bedaiwy, M. R. Hussein, C. Biscotti, and T. Falcone
Cryopreservation of intact human ovary with its vascular pedicle
Hum. Reprod., December 1, 2006; 21(12): 3258 - 3269.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. Ishii, T. Hasegawa, C.-I Pai, N. Yvgi-Ohana, R. Timberg, L. Zhao, G. Majdic, B.-c. Chung, J. Orly, and K. L. Parker
The Roles of Circulating High-Density Lipoproteins and Trophic Hormones in the Phenotype of Knockout Mice Lacking the Steroidogenic Acute Regulatory Protein
Mol. Endocrinol., October 1, 2002; 16(10): 2297 - 2309.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. Plotkin, S. Miller, S. Nakajima, E. Peskin, R. Burkman, D. Richardson, Y. Mitchel, J. Waldstreicher, M. Liu, D. Shapiro, et al.
Lowering Low Density Lipoprotein Cholesterol with Simvastatin, a Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor, Does Not Affect Luteal Function in Premenopausal Women
J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3155 - 3161.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society