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Journal of Clinical Endocrinology & Metabolism, Vol 52, 857-858, Copyright © 1981 by Endocrine Society

ARTICLES

Diurnal variation in cerebrospinal fluid prolactin concentration of the rhesus monkey

NH Kalin, TR Insel, RM Cohen, SC Risch and DL Murphy

PRL immunoreactivity in the cerebrospinal fluid (CSF) of the rhesus monkey was found found to undergo a diurnal variation. Hourly samples of CSF from four adult male rhesus monkeys showed a mean peak PRL immunoreactivity of 6.30 +/- 2.53 ng/ml at 0200 h and a mean minimum concentration at 1500 h of 3.15 +/- .68 ng/ml. To our knowledge, this is the first report of a significant diurnal variation in the concentration of an anterior pituitary peptide hormone in CSF.


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N. Garrick, L Tamarkin, P. Taylor, S. Markey, and D. Murphy
Light and propranolol suppress the nocturnal elevation of serotonin in the cerebrospinal fluid of rhesus monkeys
Science, July 29, 1983; 221(4609): 474 - 476.
[Abstract] [PDF]


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