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Journal of Clinical Endocrinology & Metabolism, Vol 52, 817-819, Copyright © 1981 by Endocrine Society

ARTICLES

In vitro inhibition of endometrial cancer growth by a neonatal rat testicular secretory product

Z Rosenwaks, HC Liu, HW Jones, L Tseng and ML Stone

The ability of a neonatal testicular product to inhibit cancer cell line growth of Mullerian origin was tested in an "in vitro" system. Preliminary experiments indicated that increasing concentration of neonatal rat testicular homogenates showed increasing endometrial cancer (HEC-1) cell growth inhibition. Further investigation revealed that testes organ culture, similarly, inhibited HEC-1 cell growth. It is, therefore, concluded that neonatal rat testes elaborated a substance (or substances) which may be effective as an anti-tumor agent.




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Copyright © 1981 by The Endocrine Society