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Journal of Clinical Endocrinology & Metabolism, Vol 52, 810-813, Copyright © 1981 by Endocrine Society


ARTICLES

Hypoparathyroidism during pregnancy: treatment with calcitriol

BL Salle, F Berthezene, FH Glorieux, EE Delvin, M Berland, L David, JP Varenne and G Putet

A pregnant woman suffering from idiopathic hypoparathyroidism was treated with calcitriol [0.5-2 micrograms/day 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3)]. Her twin infants were delivered by cesarian section at 37 weeks of gestation. Laboratory investigations in the perinatal period disclosed: 1) normal serum calcium and phosphorus levels in the mother, 2) normal babies with no clinical or biochemical signs of hyperparathyroidism, 3) a low serum level of 25-hydroxyvitamin D despite a normal serum level of 1,25-(OH)2D in the mother, and 4) a low level of 25-hydroxyvitamin D and a high level of 1,25-(OH)2D in cord serum in both infants. It is suggested that calcitriol is an effective treatment of hypoparathyroidism during pregnancy and produces no ill effects on the baby.


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Am. J. Clin. Nutr.Home page
B. L Salle, E. E Delvin, A. Lapillonne, N. J Bishop, and F. H Glorieux
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C. S. Kovacs and H. M. Kronenberg
Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation
Endocr. Rev., December 1, 1997; 18(6): 832 - 872.
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