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Journal of Clinical Endocrinology & Metabolism, Vol 52, 572-575, Copyright © 1981 by Endocrine Society

ARTICLES

Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin

WW Chin, RH Goodman, JW Jacobs, HJ Wolfe, GH Daniels and JF Habener

We report a patient who presented with a lateral neck mass and Cushing's syndrome secondary to the ectopic production of ACTH. The initial diagnosis was a nonchromaffin paraganglioma based on conventional light and electron microscopic studies. However, during this patient's hospital course, we determined that mRNA extracted from the tumor directed the translation of a calcitonin precursor in a cell- free system. This finding led to a consideration of the diagnosis of medullary thyroid carcinoma, which was then confirmed by further endocrine and histological evaluations. This is a report of the identification of a tumor type using techniques of molecular biology.




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Copyright © 1981 by The Endocrine Society