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Luteolytic Effect of D-Trp⁶-Luteinizing Hormone-Releasing Hormone in the Rhesus Monkey (Macaca mulatto)^*

Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio San Antonio, Texas 78284
Department of Pharmacology, Uniformed Services, University of Health Sciences Bethesda, Maryland 20014
The Veterans Administration Medical Center and School of Medicine, Tulane University New Orleans, Louisiana 70112

Address all correspondence and requests for reprints to: Ricardo H. Asch, M.D., Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284.

A potent agonist of luteinizing hormone, D-Trp⁶-LRH, was administered at different stages during the luteal phase of rhesus monkeys (Macaca mulatto). Luteolysis, evidenced by short luteal phases and decreased serum progesterone concentrations, was consistently induced when the analog was injected on days 3 or 5 post ovulation; however, no effect was observed when it was given on day 7 post ovulation. Increasing doses of hCG administered from days 6–10 post ovulation prevented the luteolytic effect of D-Trp⁶-LRH. The possible mechanisms of action and the potential uses of LRH analogs as contraceptive agents are discussed.

^* This work was supported in part by NIH Grant 5P30-HD-10202, Radioimmunoassay Core, Bioassay Core, and subcontract PARFR P53 (AID/DSPE-C-0035), the Program for Applied Research on Fertility Regulation of Northwestern University. Presented at the 28th Annual Meeting of the Pacific Coast Fertility Society, Scottsdale, AZ, October 15–19, 1980 (recipient of the Wyeth Award, 1980).

Received August 14, 1980.

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