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Journal of Clinical Endocrinology & Metabolism, Vol 52, 553-556, Copyright © 1981 by Endocrine Society

ARTICLES

Human T-lymphocyte subpopulations in Hashimoto's disease

GW Canonica, M Bagnasco, L Moretta, R Cocco, O Ferrini and G Giordano

An inherited defect os suppressor T-lymphocytes has been hypothesized in Hashimoto's thyroiditis. To assess this hypothesis, human T- lymphocyte subsets (TG, T lymphocytes with surface receptors for the Fc fragment of immunoglobulin G; TM, T lymphocytes with Fc receptor for immunoglobulin M) have been studied in nine patients affected by the disease. To cells have been previously shown to be suppressors in the pokeweed mitogen-stimulated B-cell differentiation and have proved abnormal in several autoimmune or immunodeficiency disorders. The number of TG lymphocytes in the patients did not differ from that in normal controls. It is possible that 1) suppressor T-lymphocytes are not involved in the pathogenesis of Hashimoto's disease or 2) antigen- specific suppressor T-cells are involved, but too are low in number with respect to total TG.




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Copyright © 1981 by The Endocrine Society