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Free Estradiol in Postmenopausal Women with and without Endometrial Cancer^*

Divisions of Reproductive Endocrinology and Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles Los Angeles, California 90024;
The Department of Gynecologic Oncology, City of Hope National Medical Center Duarte, California 91010;
The Reproductive Endocrinology Center, University of California, San Francisco San Francisco, California 94143

Address requests for reprints to: Howard L. Judd, M.D., Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of California, Los Angeles, California 90024.

To assess the role of biologically active estradiol in the development of endometrial cancer, 25 patients with endometrial tumors and a similar number of control subjects matched for age and body size were studied. No differences between the 2 groups were found for levels of total estradiol, sex hormone-binding globulin (SHBG), non-SHBG-bound estradiol, and absolute free estradiol. Body size correlated positively with levels of total, non-SHBG-bound, and absolute estradiol and negatively with SHBG levels. The obese postmenopausal women had higher total circulating levels and proportionally greater concentrations of free estradiol than nonobese subjects, suggesting a dual risk for the cellular action of circulating estradiol. These factors could contribute to the association of obesity and the occurrence of this tumor in susceptible women.

^* This work was supported in part by USPHD Grants CA-23093,RR-865, and HD-8692.

Received May 27, 1980.

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