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6βHydroxy cortisol: A Noninvasive Indicator of Enzyme Induction^*

Albert Einstein College of Medicine, Montefiore Hospial and Medical Center, Departments of Pediatrics and Clinical Research Center Bronx, New York 10467

Address all correspondence and requests for reprints to: Paul Saenger, M.D., Department of Pediatrics, Montefiore Hospital and Medical Center, 111 East 210th Street, Bronx, New York 10467.

We measured urinary 6β-hydroxycortisol (6βOHF) excretion in normal children and in children receiving anticonvulsant therapy with phenobarbital or diphenylhydantoin. 6βOHF excretion increased 4- to 7-fold during anticonvulsant therapy. The marked increase in the ratios of 6βOHF to 17- hydroxycorticosteroid and 6βOHF to free cortisol suggests that the measured increase in urinary 6βOHF may serve as an index of induction of the microsomal mixed function oxidase system.

This noninvasive approach allows rapid assessment of the effects of drugs and foreign compounds on microsomal hydroxylation of cortisol.

This convenient probe can be applied, with particular ease, to further studies in children in whom characterization of the effects of drugs and xenobiotic compounds on hepatic hydroxylation is of interest.

^* Presented in part at the Annual Meeting of The Society for Pediatric Research, San Antonio, TX, April 29 to May 2, 1980. This work wassupported by New York State Health Research Council Grant 1606, NIH Grant GM 24796-01, and Grant RR-53 from the General Research Center Branch, NIH.

Received August 7, 1980.

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