help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ohisalo, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ohisalo, J. J.

Journal of Clinical Endocrinology & Metabolism, Vol 52, 359-363, Copyright © 1981 by Endocrine Society

ARTICLES

Effects of adenosine on lipolysis in human subcutaneous fat cells

JJ Ohisalo

Adenosine inhibited isoproterenol-stimulated lipolysis in isolated human adipocytes. At a 1-microM stimulator concentration, half-maximal inhibition was observed at about 0.3 microM adenosine. The addition of adenosine deaminase to the incubation medium enhanced the stimulation of lipolysis by 1 microM isoproterenol; the enzyme was also lipolytic by itself. The combined effect of adenosine deaminase and isoproterenol was strongly inhibited by 250 nM N6-(phenylisopropyl)adenosine; the latter compound cannot be deaminated by adenosine deaminase. This inhibition was almost totally overcome by increasing the concentration of the catecholamine to 10 microM. These results suggest that human fat cells excrete adenosine, and this nucleoside reversibly inhibits the stimulation of lipolysis by catecholamines.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
T. P. Ciaraldi, A. J. Morales, M. G. Hickman, R. Odom-Ford, J. M. Olefsky, and S. S. C. Yen
Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity
J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1421 - 1425.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society