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Journal of Clinical Endocrinology & Metabolism, Vol 52, 350-353, Copyright © 1981 by Endocrine Society

ARTICLES

Secretion pattern of pro-opiomelanocortin-derived peptides by a pituitary adenoma from a patient with Cushing's disease

T Shibasaki, H Masui, G Sato, N Ling and R Guillemin

Fragments of the pituitary adenoma of a patient with Cushing's disease were maintained in defined culture medium. Immunoreactive (IR) ACTH, IR alpha-MSH, IR beta-lipotropin (beta-LPH), IR beta-endorphin, and IR gamma-MSHs secreted from the adenoma were studied with gel permeation chromatography and the respective RIAs. The adenoma secreted roughly equimolar quantities of IR beta-LPH plus IR beta-endorphin, IR gamma 3- MSHs, and IR ACTHs. It also secreted IR alpha-MSH as well as IR gamma 1- MSH, although in a much lower concentration than the above four peptides. The secreted gamma 3-MSH-like peptides were found to be glycosylated. The secretion pattern suggests that this particular adenoma processes the pro-opiomelanocortin molecule in pathways which encompass those of both the pars distalis and the pars intermedia.


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M Lis, J Julesz, J Gutkowska, and J Genest
Corticotropin-releasing activity of alpha-melanotropin
Science, February 5, 1982; 215(4533): 675 - 677.
[Abstract] [PDF]


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