help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, C.
Right arrow Articles by Yen, S. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, C.
Right arrow Articles by Yen, S. S.

Journal of Clinical Endocrinology & Metabolism, Vol 51, 1269-1273, Copyright © 1980 by Endocrine Society

ARTICLES

Acute steroidogenic responsiveness to human luteinizing hormone in hypogonadotropic hypogonadism

C Wang, CA Paulsen, BR Hopper, RW Rebar and SS Yen

The responses of circulating levels of androgens, estrogens, and their C-21 biosynthetic precursors to a 6-h constant infusion of human Lh (hLH; 2000 IU) were studied in four males with hypogonadotropic hypogonadism (HH) and compared with those in normal male controls. Although similar levels of circulating LH were achieved, the initial and secondary increases in testosterone were significantly greater in the hypogonadotropic subjects than in the normal controls. In contrast, the responses of estradiol, estrone, 17 alpha-hydroxyprogesterone, and 17 alpha-hydroxypregnenolone to exogenous hLH were significantly lower in HH than in normal controls. The data demonstrate a different pattern of testicular steroidogenic responsiveness after pharmacological doses of hLH, with increased concentrations of circulating testosterone in subjects with HH compared to a disproportionate increase in estrogen and progestin levels in normal men.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1980 by The Endocrine Society