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Intestinal Calcium Absorption in Patients with Hyperthyroidism^*

HALDIMANN BLAISE, ELAINE M. KAPTEIN, FREDERICK R. SINGER, JOHN T. NICOLOFF and SHAUL G. MASSRY

Divisions of Nephrology and Endocrinology, Department of Medicine, University of Southern California School of Medicine Los Angeles, California 90033

Address all correspondence and requests for reprints to Shaul G. Massry, M.D., Division of Nephrology, University of Southern California chool of Medicine, 2025 Zonal Avenue, Los Angeles, California 90033.

Intestinal ⁴⁷Ca absorption was measured at 2 and 24 h after isotope ingestion in six patients with hyperthyroidism and seven normal subjects. Although ⁴⁷Ca absorption was not different at 2 h, it was significantly lower (P < 0.01) after 24 h in the patients with hyperthyroidism. Factors related to the effects of thyroid hormone on intestinal function, in addition to abnormalities of vitamin D metabolism, are probably responsible for the defect.

^* This work was supported in part by General Clinical Research Grant RR-43.

Supported by Schweizerische Stiftung fur Medizinischebiologische Stipendien 835-485-77.

Recipient of a Medical Research Council of Canada fellowship.

Received April 23, 1980.