help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leyendecker, G.
Right arrow Articles by Hansmann, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leyendecker, G.
Right arrow Articles by Hansmann, M.

Journal of Clinical Endocrinology & Metabolism, Vol 51, 1214-1216, Copyright © 1980 by Endocrine Society

ARTICLES

Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea

G Leyendecker, L Wildt and M Hansmann

In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by chronic intermittent (pulsatile) administration of Gn-RH. In order to apply chronic intermittent administration of Gn-RH as a new mode of treatment of infertility in hypothalamic amenorrhea on an outpatient basis a portable device ("Zyklomat") was constructed consisting of a peristaltic pump, a computerized timing device and a Gn-RH containing bag, which delivers 50 microliters of a Gn-RH containing solution once every 90 minutes via an i.v. catheter into the circulation. It is the purpose of this communication to present this new method of treatment and the successful induction of the first two pregnancies with this method in two patients with severe hypothalamic amenorrhea.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Endocr. Rev., April 1, 2006; 27(2): 170 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
R.F. Arrais and S.A. Dib
The hypothalamus-pituitary-ovary axis and type 1 diabetes mellitus: a mini review
Hum. Reprod., February 1, 2006; 21(2): 327 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Endocrinology & Metabolism News November 2005
J. Clin. Endocrinol. Metab., November 1, 2005; 90(11): 17a - 17a.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
T. Sir-Petermann, M. Maliqueo, A. Palomino, D. Vantman, S.E. Recabarren, and L. Wildt
Episodic leptin release is independent of luteinizing hormone secretion
Hum. Reprod., November 1, 1999; 14(11): 2695 - 2699.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
E. Knobil
The Wisdom of the Body Revisited
Physiology, February 1, 1999; 14(1): 1 - 11.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. Ördög, J. R. Goldsmith, M.-D. Chen, M. A. Connaughton, J. Hotchkiss, and E. Knobil
On the Mechanism of the Positive Feedback Action of Estradiol on Luteinizing Hormone Secretion in the Rhesus Monkey
J. Clin. Endocrinol. Metab., November 1, 1998; 83(11): 4047 - 4053.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1980 by The Endocrine Society