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Journal of Clinical Endocrinology & Metabolism Vol. 51, No. 5 1078-1084
doi:10.1210/jcem-51-5-1078
Copyright © 1980 by the Endocrine Society.
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Calcium-Stimulated Vasopressin Secretion in Uremic Patients: An Effect Mediated via Parathyroid Hormone?*

MOGENS HAMMER, JØRGEN LADEFOGED, SØREN MADSEN, KLAUS ØLGAARD and ERLING TVEDEGAARD

Medical Department P, Division of Nephrology, Rigshospitalet, Copenhagen, Denmark

Address all correspondence and requests for reprints to: M. Hammer, M.D., Medical Department P 2131, Rigshospitalet, Blegdamsvej 9, DK-2100 Denmark.

The effect of whole blood ionized calcium levels on vasopressin (AVP) secretion has been studied in 12 uremic hemodialysis patients (6 nephrectomized and 6 nonnephrectomized), 6 healthy subjects, and a sprue patient, first while she was hypocalcemic and again after her blood calcium had normalized. Changes in whole blood ionized calcium wereinduced by calcium infusion (3.15 mg Ca/kg BW h–1). In uremic patients, an increase in plasma AVP took place during infusion, and the changes in AVP were correlatedto the changes in whole blood ionized calcium. In normals, no changes in AVP were found. In the sprue patient, an increase in plasma AVP correlated to whole blood ionized calciumwas found inthe hypocalcemic state, but this could not be demonstrated after treatment.

Parathyroid hormone has been shown to facilitate calcium entry into cells, and it is proposed that the pathophysiological effect of calcium on AVP secretion in uremic patientsis caused by the elevated parathyroid hormone level found in these patients.

* This work was supported by grants from the Danish Medical Research Council.

Received April 22, 1980.






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Copyright © 1980 by The Endocrine Society