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Journal of Clinical Endocrinology & Metabolism, Vol 51, 1037-1044, Copyright © 1980 by Endocrine Society
ARTICLES |
D Bression, AM Brandi, MP Martres, A Nousbaum, F Cesselin, J Racadot and F Peillon
Dopaminergic receptors were observed on the membranes of 26 human PRL- secreting adenomas. Two binding sites were found for [3H]domperidone, a selective dopamine antagonist, with a Kd1 of 0.29 +/- 0.06 nM and a Kd2 of 4.19 +/- 0.7 nM (n = 5). Bmax1 and Bmax2 (maximum numbers of binding sites, first and second sites, respectively) varied from one adenoma to another. When considering Bmax1, two different categories of PRL- secreting adenomas were distinguished, one with a concentration of receptor over 250 fmol/mg protein and others with lower concentrations of receptor (< 250 fmol/mg protein). In the latter, when considering the volume of the tumor, a higher plasma PRL level was found. Two binding sites for [3H]domperidone also were found in the normal human hypophysis with Kd values similar to those of the adenomas (0.18 +/- 0.04 and 3.95 +/- 0.35 nM). The same number of binding sites was observed in normal pituitaries and in PRL-secreting adenomas. However, when considering the density of PRL-secreting cells in the two different tissues (prolactinomas contain 2 or 3 times more PRL- secreting cells than human pituitary tissue), one may suspect a defect in the dopaminergic inhibiting control in PRL-secreting adenomas.
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