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Journal of Clinical Endocrinology & Metabolism, Vol 51, 672-673, Copyright © 1980 by Endocrine Society

ARTICLES

Somatomedin-C shares the carboxy-terminal antigenic determinants with insulin-like growth factor-I

RL Hintz and E Rinderknecht

Insulin-like growth factor I is a human plasma peptide with strong homology to human proinsulin. Many lines of evidence suggest that somatomedin-C and insulin-like growth factor I are identical molecules. However, no structural data regarding the carboxy-terminal end of somatomedin-C has yet been produced. We report a region-specific immunoassay directed against the carboxy-terminal end of insulin-like growth factor I. Somatomedin-C and insulin-like growth factor I are indistinguishable in this region-specific immunoassay. Insulin-like activity II and multiplication stimulating activity show partial cross reaction in this immunoassay. This study provides the first evidence about the carboxy-terminal portion of somatomedin-C and re-emphasizes that somatomedin-C and insulin-like growth factor I should be considered identical molecules.


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V. C. Russo, P. D. Gluckman, E. L. Feldman, and G. A. Werther
The Insulin-Like Growth Factor System and Its Pleiotropic Functions in Brain
Endocr. Rev., December 1, 2005; 26(7): 916 - 943.
[Abstract] [Full Text] [PDF]


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