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,
ZEV ROSENWAKS
,
PETER A. LEE,
MARIA D. URBAN
and
WILMA B. BIAS
Departments of Pediatrics and Obstetrics and Gynecology, Johns Hopkins University School of Medicine Baltimore, Maryland 21205
Address all correspondence and requests for reprints to: Claude J. Migeon, M.D., CMSC 3-110, The Johns Hopkins Hospital, Baltimore, Maryland 21205.
A 17-yr-old female presented with marked menstrual irregularities since menarche at age 13 yr and severe hirsutism, particularly facial, since puberty. Her disorder was shown to be related to a mild 21-hydroxylase deficiency and she was diagnosed to have an attenuated (so-called acquired) form of congenital virilizing adrenal hyperplasia.
HLA typing and ACTH testing of her parents and siblings provided evidence of a linkage between HLA and 21-hydroxylase deficiency loci. Similar observations have been made previously for the salt-losing and simple virilizing forms of congenital virilizing adrenal hyperplasia, suggesting that these two as well as the attenuated forms are allelic in regard to the 21-hydroxylase deficiency gene.
* This work was supported in part by USPHS Research Grants AM-00180-29 and RR-00052-19.
This work was supported in part by USPHS Research Grants AM-00180-29 and RR-00052-19.
This work was supported in part by USPHS Research Grants AM-00180-29 and RR-00052-19.
This work was supported in part by USPHS Research Grants AM-00180-29 and RR-00052-19.
Received February 11, 1980.
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