help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Trimble, E. R.
Right arrow Articles by Hadden, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trimble, E. R.
Right arrow Articles by Hadden, D. R.

Journal of Clinical Endocrinology & Metabolism, Vol 51, 626-631, Copyright © 1980 by Endocrine Society

ARTICLES

Plasma glucagon and insulin concentrations in acromegaly

ER Trimble, AB Atkinson, KD Buchanan and DR Hadden

Sixteen patients with clinically active acromegaly were investigated; four of these had insulin-independent diabetes mellitus. Those acromegalic subjects who were not diabetic exhibited excessive insulin responses to glucose and arginine stimulation. By contrast, plasma glucagon concentrations in these patients did not differ significantly from those in control subjects. Acromegalic patients who also had insulin-independent diabetes had a markedly reduced insulin response to glucose stimulation, while arginine-induced insulin secretion was relatively well preserved. Although there was a tendency for plasma glucagon concentrations to be higher in the diabetic than in the nondiabetic group of acromegalic subjects, this difference did not achieve statistical significance either in the basal state or during the glucose amd arginine infusion tests.


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
F. P. Dominici and D. Turyn
Growth Hormone-Induced Alterations in the Insulin-Signaling System
Experimental Biology and Medicine, March 1, 2002; 227(3): 149 - 157.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. P. Dominici, D. Cifone, A. Bartke, and D. Turyn
Alterations in the early steps of the insulin-signaling system in skeletal muscle of GH-transgenic mice
Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E447 - E454.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1980 by The Endocrine Society