help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oppizzi, G.
Right arrow Articles by Chiodini, P. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oppizzi, G.
Right arrow Articles by Chiodini, P. G.

Journal of Clinical Endocrinology & Metabolism, Vol 51, 616-619, Copyright © 1980 by Endocrine Society

ARTICLES

Homogeneity in the growth hormone-lowering effect of dopamine and somatostatin in acromegaly

G Oppizzi, L Botalla, G Verde, R Cozzi, A Liuzzi and PG Chiodini

We have studied the effect of maximally inhibiting doses of dopamine (DA) or somatostatin on GH levels in 39 acromegalic patients. The GH- lowering effects of the two drugs were highly variable in different patients. A significant correlation (r = 0.45; P < 0.01) was found between the percent changes obtained during the infusions of DA (500 microgram/min) and somatostatin (3.33 microgram/min). Pretreatment with L-sulpiride markedly blunted the inhibitory effect of DA but did not affect the response to somatostatin. We conclude that the GH-secreting cells of acromegalic patients contain separate receptors for DA and somatostatin. We hypothesize that the partial or total lack of responsiveness to DA or somatostatin may be due to the loss of receptors for these agents on the GH-secreting neoplastic cells.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
I. Yang, S. Park, J. Woo, S. Kim, J. Kim, Y. Kim, and Y. Choi
Growth Hormone Response to the Hypothalamic Somatostatinergic Activity in Acromegalic Patients
J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2492 - 2496.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1980 by The Endocrine Society