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-Hydroxyestrone: Implications in Estrogen Physiology and Pathophysiology*The Rockefeller University New York, New York 10021
Address requests for reprints to: Dr. Jack Fishman.The Rockefeller University, 1230 York Avenue, New York, New York 10021.
Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16±-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin. These biological characteristics are consistent with a hyperestrongenic response to the substance, which may be reflected in the pathology and etiology of these diseases.
* This work was supported by Grant CA-22795 from the National Cancer Institute.
Received January 17, 1980.
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