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Journal of Clinical Endocrinology & Metabolism, Vol 51, 259-264, Copyright © 1980 by Endocrine Society

ARTICLES

The inverse relationship between serum dopamine-beta-hydroxylase activity and thyroid function

JM Stolk, JH Hurst and BC Nisula

Serum dopamine-beta-hydroxylase (DBH) activity is inversely related to thyroid status in both humans and rats. The low level of serum DBH activity in hyperthyroid rats is accompanied by a rapid rate of disappearance of enzyme activity after the injection of exogenous bovine DBH. Conversely, the high level of serum DBH activity in hypothyroid rats is accompanied by a slow rate of exogenous DBH disappearance. These results suggest that the extraneuronal disposal pathway for DBH is an important factor in the regulation of the level of DBH activity in altered thyroid function in both humans and rats.




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Copyright © 1980 by The Endocrine Society