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Journal of Clinical Endocrinology & Metabolism, Vol 51, 182-184, Copyright © 1980 by Endocrine Society

ARTICLES

Evidence for a peptide similar to 16K fragment in man. Its relationship to ACTH

X Bertagna, F Girard, D Seurin, JP Luton, H Bricaire, RE Mains and BA Eipper

A radioimmunoassay directed toward the NH2-terminal region of mouse pro- ACTH/endorphin (called 16K fragment) was used to examine human samples. Culture media from two corticotropic adenomas and plasmas from 11 patients with various ACTH hypersecretory syndromes gave parallel displacement curves; displacement curves for human samples were not parallel to purified mouse 16K fragment. Following sodium dodecyl sulfate polyacrylamide gel electrophoresis of culture medium from one adenoma, a major peak of 16K fragment immunoreactivity with an apparent molecular weight of ca. 16,000 was detected. A significant correlation (r = 0.963 ; p less than 0.001) was found between immunoreactive 16K fragment and ACTH in the patients' plasmas. These data indicate that a peptide similar to 16K fragment exists in man ; that human and mouse 16K fragment are immunologically distinguishable and that human 16K fragment appears to be secreted concomitantly with ACTH.


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