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Journal of Clinical Endocrinology & Metabolism, Vol 50, 1147-1148, Copyright © 1980 by Endocrine Society

ARTICLES

Evidence for gamma-MSH-like immunoreactivity in ectopic ACTH-producing tumors

Y Nakai, I Tanaka, J Fukata, K Nakao, S Oki, S Takai and H Imura

Using a specific radioimmunoassay for gamma-MSH, a predicted peptide in the cryptic N-terminal portion of the adrenocorticotropin-beta- lipotropin precursor, gamma-MSH-like immunoreactivity (gamma-MLI) was detected in two ectopic ACTH producing tumors. Gel chromatographic studies on Bio-Gel P-60 revealed one or two peaks of gamma-MLI; one was eluted near th elution position of beta-LPH, compatible with gamma-MLI in human pituitary and the other emerged near the position of beta- endorphin. These results indicate that ectopic ACTH-producing tumors eleborate not only ACTH, beta-endorphin but also gamma-MLI.




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