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Journal of Clinical Endocrinology & Metabolism, Vol 50, 1131-1134, Copyright © 1980 by Endocrine Society

ARTICLES

Unchanged arginine-induced stimulation of insulin, glucagon, growth hormone, and prolactin after pretreatment with indomethacin in normal man

H Vierhapper, P Bratusch-Marrain and W Waldhausl

The arginine-induced release of insulin, glucagon, GH, and PRL was studied in eight normal male volunteers. Pretreatment with indomethacin (150 mg for 3 days) failed to modify the effect of arginine on the release of these hormones. As both indomethacin and acetylsalicylic acid are potent inhibitors of the endogenous prostaglandin synthesis, these results indicate that the effect of acetylsalicylic acid on insulin and glucagon secretion, as described by others, seems to be unrelated to the suppression of endogenous prostaglandin synthesis.




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Copyright © 1980 by The Endocrine Society