Journal of Clinical Endocrinology & Metabolism, Vol 50, 1100-1104, Copyright © 1980 by Endocrine Society

ARTICLES

Prolonged biphasic response of plasma testosterone to single intramuscular injections of human chorionic gonadotropin

RS Padron, J Wischusen, B Hudson, HG Burger and DM de Kretser

The response of plasma testosterone to varying doses of hCG (0--6000 IU) given as a single im injection has been evaluated in normal men. After an initial rise at 2 h, the levels of testosterone demonstrated a secondary rise, reaching a peak 48 h after the im injection. The magnitude of the response varied directly with the dose of hCG used, and at the highest dose (6000 IU) testosterone levels were still elevated 6 days after administration. Plasma estradiol levels showed a dose-dependent rise, with peak levels being attained 24 h after hCG. The prolonged response of plasma testosterone to a single injection of hCG should prompt a reevaluation of diagnostic and therapeutic regimens using this agent.

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