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Journal of Clinical Endocrinology & Metabolism, Vol 50, 972-974, Copyright © 1980 by Endocrine Society

ARTICLES

Sulfhydryl group modulation and triiodothyronine generation in the human polymorphonuclear leukocyte

KA Woeber

The induction of phagocytosis in the human polymorphonuclear leukocyte and the attendant decrease in endogenous sulfhydryl group content were accompanied by a depression of the generation by the 27,000 x g particulate fraction of L-T3 and L-rT3 from substrate L-T4. A direct correlation between endogenous sulfhydryl group content and L-T3- generating activity was found to exist. The inhibitory influence of phagocytosis was prevented when phagocytosis was induced in the presence of a sulfhydryl group protector.




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Copyright © 1980 by The Endocrine Society