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Journal of Clinical Endocrinology & Metabolism, Vol 50, 597-599, Copyright © 1980 by Endocrine Society

ARTICLES

Failure of naloxone to influence plasma growth hormone, prolactin, and cortisol secretions induced by insulin hypoglycemia

I Wakabayashi, R Demura, N Miki, E Ohmura, H Miyoshi and K Shizume

The effect of naloxone, a specific antagonist of opioid peptides, on plasma, GH, PRL, and cortisol responses to insulin-induced hypoglycemia was studied in five healthy male subjects. The iv administration of regular insulin (0.15 U/kg) led to similar degrees of hypoglycemia on control and experimental days. Plasma GH, PRL, and cortisol levels rose significantly in response to insulin-induced hypoglycemia. A 2-h infusion of naloxone (0.8 mg/h) started 30 min before insulin injection did not alter either basal hormone levels or the hormone responses to insulin-induced hypoglycemia. These results suggest that endogenous opioid peptides do not play a major role in GH, PRL, or cortisol secretion induced by insulin hypoglycemia.




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