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Journal of Clinical Endocrinology & Metabolism, Vol 50, 480-484, Copyright © 1980 by Endocrine Society

ARTICLES

Stimulation of 1,25-dihydroxyvitamin D production by parathyroid hormone and hypocalcemia in man

B Lund, OH Sorensen, B Lund, JE Bishop and AW Norman

The serum levels of 1.25-dihydroxycholecalciferol [1,25(OH)2D3] were increased in five patients with primary hyperparathyroidism [60 +/- 13 (SD) pg/ml; normal value, 33 +/- 15 (SD) pg/ml] but fell rapidly after parathyroidectomy to values of 23 +/- 9 (SD) pg/ml. This was accompanied by parallel decreases in the serum concentrations of calcium and immunoreactive parathyroid hormone. Over the following 5-- 35 days, the serum 1,25(OH)2D3 concentrations increased markedly to levels of 59 +/- 17 (SD) pg/ml, which could most likely be explained by a stimulatory effect of the hypocalcemia per se on the renal production of 1,25(OH)2D3.


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T. Shinki, Y. Ueno, H. F. DeLuca, and T. Suda
Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1alpha -hydroxylase gene in normocalcemic rats
PNAS, July 6, 1999; 96(14): 8253 - 8258.
[Abstract] [Full Text] [PDF]


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