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Journal of Clinical Endocrinology & Metabolism, Vol 50, 408-410, Copyright © 1980 by Endocrine Society

ARTICLES

Suppression of prolactin and gonadotropin secretion in post-menopausal women by 2-hydroxyestrone

JS Schinfeld, D Tulchinsky, I Schiff and J Fishman

An infusion of 2-hydroxyestrone given to estrogen primed post- menopausal women resulted in a rapid and total suppression of serum prolactin. Serum LH responded with an initial rise followed by a 30% decrease below baseline values. Serum FSH exhibited a significant suppression below preinfusion levels. The catechol estrogen had no effect on serum LH, FSH and PRL in post-menopausal women who were not pretreated with estrogens. This impact of 2-hydroxyestrone on pituitary hormone secretion provides for the physiological role of this non- uterotropic estrogen in the neuroendocrine mechanisms of the human.


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J Fishman and D Tulchinsky
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