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Journal of Clinical Endocrinology & Metabolism, Vol 50, 405-407, Copyright © 1980 by Endocrine Society

ARTICLES

Interaction of somatomedin-C with an antibody directed against the synthetic C-peptide region of insulin-like growth factor-I

RL Hintz, F Liu, LB Marshall and D Chang

Insulin-like growth factor-I is a human plasma peptide with strong structural homology to human prosinsulin. This peptide has been classified as a somatomedin on the basis of its biological actions and growth hormone dependence. We have generated an antibody to the synthetic 12 amino acid C-peptide region of insulin-like growth factor- I and used it to compare three somatomedin preparations to insulin-like growth factor-I. We also compared these somatomedin preparations to insulin-like growth factor-I using the standard SM-C RIA. We conclude that insulin-like growth factor-I and somatomedin-C behave identically in these two RIA's and are very similar if not identical molecules.




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