Journal of Clinical Endocrinology & Metabolism, Vol 50, 377-379, Copyright © 1980 by Endocrine Society

ARTICLES

Effect of the menstrual cycle on calcium-regulating hormones in the normal young woman

DT Baran, MP Whyte, MR Haussler, LJ Deftos, E Slatopolsky and LV Avioli

To examine the effect of estrogens on circulating levels of calcium- regulating hormones, total serum calcium, ionized calcium, inorganic phosphate, immunoreactive parathyroid hormone, calcitonin, 1,25- dihydroxyvitamin D, and estradiol (E2) levels were assayed on menstrual cycle days 3 and 13 in 12 healthy young women. Despite a 3-fold increase in serum E2 levels by midcycle, no differences in the other factors were observed. Furthermore, iv infusion of calcium (3 mg/kg over a 10-min period) produced similar changes in the serum levels of immunoreactive parathyroid hormone and calcitonin on days 3 and 13 in 8 women. Our findings suggest that in normal menstruating women, endogenous increases in E2 neither directly nor indirectly stimulate 1,25-dihydroxyvitamin D production, nor do they affect circulating levels of the hormones known to influence calcium homeostasis in man.

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