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Journal of Clinical Endocrinology & Metabolism, Vol 50, 294-297, Copyright © 1980 by Endocrine Society

ERRATA

Effects of physiological infusion of epinephrine in normal humans: relationship between the metabolic response and beta-adrenergic binding [retracted by Felig P, Sherwin RS. In: J Clin Endocrinol Metab 1980 Nov;51(5):1201]

VR Soman, H Shamoon and RS Sherwin

In normal humans, infusion of epinephrine for 4 h increased plasma epinephrine to 411 +/- 38 pg/ml but had no significant effect on palsma insulin or glucagon levels. Epinephrine produced a prompt 45% rise in glucose output (P less than 0.01) and a 120% rise in FFA (P less than 0.001), both of which declined to basal levels by 60-90 min. Glucose clearance decreased by 25% (P less than 0.005) and remained suppressed for 4 h. The binding of [125I]hydroxybenzylpindolol to lymphocytes was unchanged after epinephrine infusion. We conclude that in normal humans 1) physiological increments in epinephrine have a persistent effect in decreasing glucose clearance but only transiently increase hepatic glucose output and FFA levels and 2) this refractoriness of liver and adipose tissue to epinephrine occurs without a concomitant decrease in beta-adrenergic binding to lymphocytes.


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