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Journal of Clinical Endocrinology & Metabolism, Vol 50, 226-229, Copyright © 1980 by Endocrine Society

ARTICLES

Transient hypothyroidism after iodine-131 treatment of thyrotoxicosis

JS Sawers, AD Toft, WJ Irvine, NS Brown and J Seth

Thirty consecutive patients with thyrotoxicosis were followed up at monthly intervals for 6 months after treatment with iodine-131. Serum total T4, serum total T3, and serum TSH response to TRH were measured at each review. Biochemical evidence of hypothyroidism (low T4 raised basal TSH) developed in 18 patients 1-4 months after treatment. In 5 of these patients, symptoms and signs of hypothyroidism remained absent or minimal and spontaneous recovery of thyroid function occurred during the ensuing 2 months. If biochemical hypothyroidism occurs during the first 6 months after radioiodine therapy, it is recommended that T4 replacement be withheld for 2 months unless the severity of symptoms demands treatment.


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