This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by OKI, S. Articles by IMURA, H. Search for Related Content PubMed PubMed Citation Articles by OKI, S. Articles by IMURA, H.

Plasma β-Endorphin Responses to Somatostatin, Thyrotropin-Releasing Hormone, or Vasopressin in Nelson's Syndrome

Second Division, Department of Internal Medicine, Kyoto University Faculty of Medicine, Sakyo-ku,Kyoto 606 Japan

Address requests for reprints to: Dr. Shogo Oki, Second Division, Department of Internal Medicine, Kyoto University, Faculty of Medicine, 54 Shogoin Kawaharacho, Sakyo-ku, Kyoto 606, Japan.

To elucidate the regulation of secretion of β3-endorphin in Nelson's syndrome, both ACTH and β-endorphin were measured using RIA. We found that β8-endorphin and ACTH were secreted concomitantly in responses to the administration of lysine-8-vasopressin and TRH. Conversely, the administration of somatostatin to this patient reduced the secretion of both β-endorphin and ACTH. Thus, β8-endorphin is probably secreted coordinately with ACTH in patients with Nelson's syndrome.

Received June 8, 1979.