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Sexual Precocity in a Female Infant due to Feminizing Adrenal Carcinoma^*

Departments of Pediatrics and Obstetrics and Gynecology, Medical University of South Carolina Charleston, South Carolina 29403

Address requests for reprints to: H. Oliver Williamson, M.D., Section on Reproductive Endocrinology, Department of Obstetrics and Gynecology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29403.

A 21-month-old female with virilizing and then feminizing sexual precocity due to an adrenal adenocarcinoma treated surgically at 21 months of age is reported. Urinary neutral 17-ketosteroids were 116 and 106 mg/24 h and correlated with high plasma levels (1408µg/dl) of dehyroepiandrosterone sulfate. Plasma estradiol (17 ng/dl) and urinary estradiol levels (6.3 and 7.1 µ/24 h) were elevated to adult levels and associated with breast development, clitoral enlargement, and an estrogenized vagina. Plasma cortisol was normal. The patient remains healthy over 10 yr later, although capsular invasion was present.

^* This work was supported in part by the General Clinical Research Center, Medical University of South Carolina (Grant RR-1070).

Received April 10, 1979.