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Lack of Response of Serum Somatomedin to Hyperprolactinemia in Humans^*

Cancer Research Institute, Metabolic Research Unit and General ClinicalResearch Center, University of California, San Francisco, California 94143

Address all correspondence and requests for reprints to: Dr. E. Martin Spencer, Children's Hospital, 3700 California Street, San Francisco, California 94118

Because animal experiments have suggested that PRL might regulate the serum somatomedin (SM) concentration, the effect of sustained hyperprolactinemia on the serum SM level was studied in patients with proven pituitary microadenomas. PRL was determined by RIA. SM was measured on the same sample by a human placental membrane radioreceptor assay in which all SMs cross-react. The mean serum SM (±SE) in 16 females with elevated PRL levels from 68–21,000 ng/ml was 0.97 ± 0.08 U/ml. Thiswas not statistically different from that of 29 normal women, (P > 0.2). The mean SM for the 3 male patients with serum PRL levels from 570–5,050 ng/ml was in the lower range for normal males. There was no correlation in either group between the serum SM and PRL levels. These results indicate that PRL is not a major regulator of the serum SM concentration in man (J Clin Endocrinol Metab 50: 182,1980)

^* This work was supported by grants from the American Cancer Society (BC-222) and NIH (AM-21301).

Received January 2, 1979.

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