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The Metabolism of 3,3'-Diiodothyronine in Man^*

Department of Medicine, University of Berne Berne Division of Endocrinology, Thyroid Research Unit, Department of Medicine, University of Geneva Geneva, Switzerland

Address requests for reprints to: A. G. Burger, M.D., Thyroid Research Unit, Hopital Cantonal, CH-1211 Geneva 4, Switzerland.

The production rate of 3,3'-Diiodothyronine (3,3'-T₂) was measured in five healthy subjects after a single injection of [¹²⁵I]3,3'-T₂. The [^I25I]3,3'-T² was measured by immunoprecipitation. To reduce the large amount of nonspecific serum radioactivity (iodides, 3,3'-T₂ metabolites, and proteinbound iodine), the sera were treated before the immunoprecipitation with an anion exchanger and polyethylene glycol (final concentration, 10%). The noncompartmental analysis of the data gave the following results: MCR, 0.52 ± 0.07 liters/min or 926 ± 142 liters/day (mean ± SD); and production rate, 23.7 ± 8.2 ng/min or 34 ± 12 µg/day.

^* This work was supported by the Swiss National Research Foundation (Grant 3.516-0.75).

Received February 2, 1979.