| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
,
JAMES R. GIVENS and
ABBAS E. KITABCHI
Departments of Pediatrics, Medicine, and Obstetrics and Gynecology and the Clinical Research Center,University of Tennessee Center for the Health Sciences Memphis, Tennessee 38163
Address requests for reprints to: Dr. George A. Burghen, University of Tennessee Center for the Health Sciences, Department of Pediatrics, 951 Court Avenue, Memphis, Tennessee 38163.
We evaluated basal plasma total immunoreactive insulin (insulin), androstenedione, and testosterone in 14 obesewomen: 8 with polycystic ovarian disease (PCOD) and 6 obese controls. All 3 hormones were significantly elevated (P < 0.02 to P < 0.001) in PCOD patients. A significant correlation amon basal levels of plasma insulin, androstenedione, and testosterone was demonstrated. The PCOD group had significantly higher levels of glucose at 1, 2, and 3 h, with similar significant increases in plasma insulin levels at 0, 2, and 3 h. A significant correlation was found between plasma insulin response areas and plasma testosterone (P < 0.001) in the control and PCOD patients. These studies demonstrate that hyperandrogenism correlates with hyperinsulinism.
* This work was supported in part by NIH General Clinical Research Center Grant RR-00211, USPHS Grants RR-05423 and 5K04-HD 70462, and Training Grant in Endocrinology-Metabolism-Diabetes AM-07088.
Recipient of USPHS Research Career Development Award 5K04- HD-70462.
Received January 29, 1979.
This article has been cited by other articles:
 |
|
 |
|
  I. J. Rzepczynska, P. C. Piotrowski, D. H. Wong, A. B. Cress, J. Villanueva, and A. J. Duleba Role of Isoprenylation in Simvastatin-Induced Inhibition of Ovarian Theca-Interstitial Growth in the Rat Biol Reprod, November 1, 2009; 81(5): 850 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Vassiliadi, T. M. Barber, B. A. Hughes, M. I. McCarthy, J. A. H. Wass, S. Franks, P. Nightingale, J. W. Tomlinson, W. Arlt, and P. M. Stewart Increased 5{alpha}-Reductase Activity and Adrenocortical Drive in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., September 1, 2009; 94(9): 3558 - 3566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Shi, M. K. Dyck, R. R. E. Uwiera, J. C. Russell, S. D. Proctor, and D. F. Vine A Unique Rodent Model of Cardiometabolic Risk Associated with the Metabolic Syndrome and Polycystic Ovary Syndrome Endocrinology, September 1, 2009; 150(9): 4425 - 4436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Iwase, M. Goto, T. Harata, S. Takigawa, T. Nakahara, K. Suzuki, S. Manabe, and F. Kikkawa Insulin Attenuates the Insulin-Like Growth Factor-I (IGF-I)-Akt Pathway, not IGF-I-Extracellularly Regulated Kinase Pathway, in Luteinized Granulosa Cells with an Increase in PTEN J. Clin. Endocrinol. Metab., June 1, 2009; 94(6): 2184 - 2191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. F. Svendsen, L. Nilas, K. Norgaard, J.-E. B. Jensen, and S. Madsbad Obesity, body composition and metabolic disturbances in polycystic ovary syndrome Hum. Reprod., September 1, 2008; 23(9): 2113 - 2121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Demissie, M. Lazic, E. M. Foecking, F. Aird, A. Dunaif, and J. E. Levine Transient prenatal androgen exposure produces metabolic syndrome in adult female rats Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E262 - E268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Yahyaoui, I. Esteva, J. J. Haro-Mora, M. C. Almaraz, S. Morcillo, G. Rojo-Martinez, J. Martinez, J. M. Gomez-Zumaquero, I. Gonzalez, V. Hernando, et al. Effect of Long-Term Administration of Cross-Sex Hormone Therapy on Serum and Urinary Uric Acid in Transsexual Persons J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2230 - 2233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chakrabarty and M. Nagamani Peripubertal Hyperinsulinemia Upregulates Phosphatidylinositol 3-Kinase/Akt Pathway in Rat Ovaries Reproductive Sciences, March 1, 2008; 15(3): 274 - 284. [Abstract] [PDF]
|
|
|
|
|
|
P. Vigil, P. Contreras, J. L. Alvarado, A. Godoy, A. M. Salgado, and M. E. Cortes Evidence of subpopulations with different levels of insulin resistance in women with polycystic ovary syndrome Hum. Reprod., November 1, 2007; 22(11): 2974 - 2980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Ma, L. Fan, Y. Meng, Z. Hou, Y.-D. Mao, W. Wang, W. Ding, and J.-Y. Liu Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome Mol. Hum. Reprod., August 1, 2007; 13(8): 527 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Seow, C.-C. Juan, L.-T. Ho, Y.-P. Hsu, Y.-H. Lin, L.-W. Huang, and J.-L. Hwang Adipocyte resistin mRNA levels are down-regulated by laparoscopic ovarian electrocautery in both obese and lean women with polycystic ovary syndrome Hum. Reprod., April 1, 2007; 22(4): 1100 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen, D. Yang, L. Li, S. Feng, and L. Wang Abnormal glucose tolerance in Chinese women with polycystic ovary syndrome Hum. Reprod., August 1, 2006; 21(8): 2027 - 2032. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mohlig, A. Jurgens, J. Spranger, K. Hoffmann, M. O Weickert, H. W Schlosser, T. Schill, G. Brabant, A. Schuring, A. F H Pfeiffer, et al. The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome. Eur. J. Endocrinol., July 1, 2006; 155(1): 127 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rautio, J.S. Tapanainen, A. Ruokonen, and L.C. Morin-Papunen Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study Hum. Reprod., June 1, 2006; 21(6): 1400 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kwintkiewicz, R. Z. Spaczynski, N. Foyouzi, T. Pehlivan, and A. J. Duleba Insulin and Oxidative Stress Modulate Proliferation of Rat Ovarian Theca-Interstitial Cells Through Diverse Signal Transduction Pathways Biol Reprod, June 1, 2006; 74(6): 1034 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Topcu, M. Caliskan, E. E. Ozcimen, D. Tok, A. Uckuyu, D. Erdogan, H. Gullu, A. Yildirir, H. Zeyneloglu, and H. Muderrisoglu Do young women with polycystic ovary syndrome show early evidence of preclinical coronary artery disease? Hum. Reprod., April 1, 2006; 21(4): 930 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Gonzalez, N S Rote, J Minium, and J P Kirwan In vitro evidence that hyperglycemia stimulates tumor necrosis factor-{alpha} release in obese women with polycystic ovary syndrome. J. Endocrinol., March 1, 2006; 188(3): 521 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Eisenhardt, N. Schwarzmann, V. Henschel, A. Germeyer, M. von Wolff, A. Hamann, and T. Strowitzki Early Effects of Metformin in Women with Polycystic Ovary Syndrome: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 946 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chakrabarty, B. T. Miller, T. J. Collins, and M. Nagamani Ovarian Dysfunction in Peripubertal Hyperinsulinemia Reproductive Sciences, February 1, 2006; 13(2): 122 - 129. [Abstract] [PDF]
|
|
|
|
|
|
E. Lystedt, H. Westergren, J. Brynhildsen, L. Lindh-Astrand, J. Gustavsson, F. H Nystrom, M. Hammar, and P. Stralfors Subcutaneous adipocytes from obese hyperinsulinemic women with polycystic ovary syndrome exhibit normal insulin sensitivity but reduced maximal insulin responsiveness Eur. J. Endocrinol., December 1, 2005; 153(6): 831 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Urbanek, A. Woodroffe, K. G. Ewens, E. Diamanti-Kandarakis, R. S. Legro, J. F. Strauss III, A. Dunaif, and R. S. Spielman Candidate Gene Region for Polycystic Ovary Syndrome on Chromosome 19p13.2 J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6623 - 6629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Diamanti-Kandarakis and C. Piperi Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth Hum. Reprod. Update, November 1, 2005; 11(6): 631 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gonzalez, J. Minium, N. S. Rote, and J. P. Kirwan Hyperglycemia Alters Tumor Necrosis Factor-{alpha} Release from Mononuclear Cells in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5336 - 5342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I.A.A. Penna, P.R.B. Canella, R.M. Reis, M.F. Silva de Sa, and R.A. Ferriani Acarbose in obese patients with polycystic ovarian syndrome: a double-blind, randomized, placebo-controlled study Hum. Reprod., September 1, 2005; 20(9): 2396 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ortega-Gonzalez, S. Luna, L. Hernandez, G. Crespo, P. Aguayo, G. Arteaga-Troncoso, and A. Parra Responses of Serum Androgen and Insulin Resistance to Metformin and Pioglitazone in Obese, Insulin-Resistant Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., March 1, 2005; 90(3): 1360 - 1365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Volpi, S. A. Lieberman, D. M. Ferrer, C. R. Gilkison, B. B. Rasmussen, M. Nagamani, and R. J. Urban The Relationships Between Testosterone, Body Composition, and Insulin Resistance: A lesson from a case of extreme hyperandrogenism Diabetes Care, February 1, 2005; 28(2): 429 - 432. [Full Text] [PDF]
|
|
|
|
|
|
C Ortega-Gonzalez, L Cardoza, B Coutino, R Hidalgo, G Arteaga-Troncoso, and A Parra Insulin sensitizing drugs increase the endogenous dopaminergic tone in obese insulin-resistant women with polycystic ovary syndrome J. Endocrinol., January 1, 2005; 184(1): 233 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Seow, C.-C. Juan, Y.-P. Hsu, L.-T. Ho, Y.-Y. Wang, and J.-L. Hwang Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles Hum. Reprod., January 1, 2005; 20(1): 117 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mioni, S. Chiarelli, N. Xamin, L. Zuliani, M. Granzotto, B. Mozzanega, P. Maffei, C. Martini, S. Blandamura, N. Sicolo, et al. Evidence for the Presence of Glucose Transporter 4 in the Endometrium and Its Regulation in Polycystic Ovary Syndrome Patients J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 4089 - 4096. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.J. Duleba, N. Foyouzi, M. Karaca, T. Pehlivan, J. Kwintkiewicz, and H.R. Behrman Proliferation of ovarian theca-interstitial cells is modulated by antioxidants and oxidative stress Hum. Reprod., July 1, 2004; 19(7): 1519 - 1524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Norman, M. Noakes, R. Wu, M. J. Davies, L. Moran, and J. X. Wang Improving reproductive performance in overweight/obese women with effective weight management Hum. Reprod. Update, May 1, 2004; 10(3): 267 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cibula Is insulin resistance an essential component of PCOS?: The influence of confounding factors Hum. Reprod., April 1, 2004; 19(4): 757 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-M. Seow, C.-C. Juan, L.-Y. Wu, Y.-P. Hsu, W.-M. Yang, Y.-L. Tsai, J.-L. Hwang, and L.-T. Ho Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance Hum. Reprod., January 1, 2004; 19(1): 48 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. De Leo, A. la Marca, and F. Petraglia Insulin-Lowering Agents in the Management of Polycystic Ovary Syndrome Endocr. Rev., October 1, 2003; 24(5): 633 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Morin-Papunen, K. Rautio, A. Ruokonen, P. Hedberg, M. Puukka, and J. S. Tapanainen Metformin Reduces Serum C-Reactive Protein Levels in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4649 - 4654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Haakova, D. Cibula, K. Rezabek, M. Hill, M. Fanta, and J. Zivny Pregnancy outcome in women with PCOS and in controls matched by age and weight Hum. Reprod., July 1, 2003; 18(7): 1438 - 1441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Legro Polycystic Ovary Syndrome and Cardiovascular Disease: A Premature Association? Endocr. Rev., June 1, 2003; 24(3): 302 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tafeit, R. Moller, S. Rackl, A. Giuliani, W. Urdl, U. Freytag, K. Crailsheim, K. Sudi, and R. Horejsi Subcutaneous Adipose Tissue Pattern in Lean and Obese Women with Polycystic Ovary Syndrome Experimental Biology and Medicine, June 1, 2003; 228(6): 710 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Morin-Papunen, I. Vauhkonen, R. Koivunen, A. Ruokonen, H. Martikainen, and J. S. Tapanainen Metformin Versus Ethinyl Estradiol-Cyproterone Acetate in the Treatment of Nonobese Women with Polycystic Ovary Syndrome: A Randomized Study J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 148 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kaaks, A. Lukanova, and M. S. Kurzer Obesity, Endogenous Hormones, and Endometrial Cancer Risk: A Synthetic Review Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1531 - 1543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bagis, A. Gokcel, H. B. Zeyneloglu, E. Tarim, E. B. Kilicdag, and B. Haydardedeoglu The Effects of Short-Term Medroxyprogesterone Acetate and Micronized Progesterone on Glucose Metabolism and Lipid Profiles in Patients with Polycystic Ovary Syndrome: A Prospective Randomized Study J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4536 - 4540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Seminara and W. F. Crowley Jr. Genetic Approaches to Unraveling Reproductive Disorders: Examples of Bedside to Bench Research in the Genomic Era Endocr. Rev., June 1, 2002; 23(3): 382 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Homburg Should patients with polycystic ovarian syndrome be treated with metformin?: A note of cautious optimism Hum. Reprod., April 1, 2002; 17(4): 853 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Oh, E. Barrett-Connor, N. M. Wedick, and D. L. Wingard Endogenous Sex Hormones and the Development of Type 2 Diabetes in Older Men and Women: the Rancho Bernardo Study Diabetes Care, January 1, 2002; 25(1): 55 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Koivunen, L. C. Morin-Papunen, A. Ruokonen, J. S. Tapanainen, and H. K. Martikainen Ovarian steroidogenic response to human chorionic gonadotrophin in obese women with polycystic ovary syndrome: effect of metformin Hum. Reprod., December 1, 2001; 16(12): 2546 - 2551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ciotta, A. E. Calogero, M. Farina, V. De Leo, A. La Marca, and A. Cianci Clinical, endocrine and metabolic effects of acarbose, an {alpha}-glucosidase inhibitor, in PCOS patients with increased insulin response and normal glucose tolerance Hum. Reprod., October 1, 2001; 16(10): 2066 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Duleba, T. Pehlivan, R. Carbone, and R. Z. Spaczynski Activin Stimulates Proliferation of Rat Ovarian Thecal-Interstitial Cells Biol Reprod, September 1, 2001; 65(3): 704 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Shalev, S. Goldman, and I. Ben-Shlomo The balance between MMP-9 and MMP-2 and their tissue inhibitor (TIMP)-1 in luteinized granulosa cells: comparison between women with PCOS and normal ovulatory women Mol. Hum. Reprod., April 1, 2001; 7(4): 325 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ibáñez, J. DiMartino-Nardi, N. Potau, and P. Saenger Premature Adrenarche--Normal Variant or Forerunner of Adult Disease? Endocr. Rev., December 1, 2000; 21(6): 671 - 696. [Abstract] [Full Text]
|
|
|
|
|
|
J. W. M. Martens, D. H. Geller, W. Arlt, R. J. Auchus, V. S. Ossovskaya, H. Rodriguez, A. Dunaif, and W. L. Miller Enzymatic Activities of P450c17 Stably Expressed in Fibroblasts from Patients with the Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4338 - 4346. [Abstract] [Full Text]
|
|
|
|
|
|
L. C. Morin-Papunen, I. Vauhkonen, R. M. Koivunen, A. Ruokonen, H. K. Martikainen, and J. S. Tapanainen Endocrine and Metabolic Effects of Metformin Versus Ethinyl Estradiol-Cyproterone Acetate in Obese Women with Polycystic Ovary Syndrome: A Randomized Study J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3161 - 3168. [Abstract] [Full Text]
|
|
|
|
|
|
P. J. Marsden, A. P. Murdoch, and R. Taylor Adipocyte insulin action in hypogonadotrophic hypogonadism Hum. Reprod., August 1, 2000; 15(8): 1672 - 1678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Lobo and E. Carmina The Importance of Diagnosing the Polycystic Ovary Syndrome Ann Intern Med, June 20, 2000; 132(12): 989 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.D. Murray, R.M. Davison, R.C. Russell, and G.S. Conway Clinical presentation of PCOS following development of an insulinoma: Case Report Hum. Reprod., January 1, 2000; 15(1): 86 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ciotta, V. De Leo, F. Galvani, A. La Marca, and A. Cianci Endocrine and metabolic effects of octreotide, a somatostatin analogue, in lean PCOS patients with either hyperinsulinaemia or lean normoinsulinaemia Hum. Reprod., December 1, 1999; 14(12): 2951 - 2958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lemieux, G. F. Lewis, A. Ben-Chetrit, G. Steiner, and E. M. Greenblatt Correction of Hyperandrogenemia by Laparoscopic Ovarian Cautery in Women with Polycystic Ovarian Syndrome Is Not Accompanied by Improved Insulin Sensitivity or Lipid-Lipoprotein Levels J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 4278 - 4282. [Abstract] [Full Text]
|
|
|
|
|
|
M.F.M. Mitwally, N.K. Kuscu, and T.M. Yalcinkaya High ovulatory rates with use of troglitazone in clomiphene-resistant women with polycystic ovary syndrome Hum. Reprod., November 1, 1999; 14(11): 2700 - 2703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Poretsky, N. A. Cataldo, Z. Rosenwaks, and L. C. Giudice The Insulin-Related Ovarian Regulatory System in Health and Disease Endocr. Rev., August 1, 1999; 20(4): 535 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wahrenberg, I. Ek, S. Reynisdottir, K. Carlström, A. Bergqvist, and P. Arner Divergent Effects of Weight Reduction and Oral Anticonception Treatment on Adrenergic Lipolysis Regulation in Obese Women with the Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., June 1, 1999; 84(6): 2182 - 2187. [Abstract] [Full Text]
|
|
|
|
|
|
A.M. Fulghesu, F. Cucinelli, V. Pavone, F. Murgia, M. Guido, A. Caruso, S. Mancuso, and A. Lanzone Changes in luteinizing hormone and insulin secretion in polycystic ovarian syndrome Hum. Reprod., March 1, 1999; 14(3): 611 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Legro, A. R. Kunselman, W. C. Dodson, and A. Dunaif Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 165 - 169. [Abstract] [Full Text]
|
|
|
|
|
|
M. P. Diamond, D. Grainger, M. C. Diamond, R. S. Sherwin, and R. A. DeFronzo Effects of Methyltestosterone on Insulin Secretion and Sensitivity In Women J. Clin. Endocrinol. Metab., December 1, 1998; 83(12): 4420 - 4425. [Abstract] [Full Text]
|
|
|
|
|
|
R. S. Legro, D. Finegood, and A. Dunaif A Fasting Glucose to Insulin Ratio Is a Useful Measure of Insulin Sensitivity in Women with Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2694 - 2698. [Abstract] [Full Text]
|
|
|
|
|
|
E. Diamanti-Kandarakis, A. Mitrakou, S. Raptis, G. Tolis, and A. J. Duleba The Effect of a Pure Antiandrogen Receptor Blocker, Flutamide, on the Lipid Profile in the Polycystic Ovary Syndrome J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2699 - 2705. [Abstract] [Full Text]
|
|
|
|
|
|
A. Dunaif Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis Endocr. Rev., December 1, 1997; 18(6): 774 - 800. [Abstract] [Full Text]
|
|
|
|
|
|
P. Pigny, R. Desailloud, C. Cortet-Rudelli, A. Duhamel, D. Deroubaix-Allard, A. Racadot, and D. Dewailly Serum {alpha}-Inhibin Levels in Polycystic Ovary Syndrome: Relationship to the Serum Androstenedione Level J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1939 - 1943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mesiano, S. L. Katz, J. Y. Lee, and R. B. Jaffe Insulin-Like Growth Factors Augment Steroid Production and Expression of Steroidogenic Enzymes in Human Fetal Adrenal Cortical Cells: Implications for Adrenal Androgen Regulation J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1390 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ek, P. Arner, A. Bergqvist, K. Carlstrom, and H. Wahrenberg Impaired Adipocyte Lipolysis in Nonobese Women with the Polycystic Ovary Syndrome: A Possible Link to Insulin Resistance? J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1147 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Andersson, L.-A. Mattsson, L. Hahn, L. Lapidus, G. Holm, B.-A. Bengtsson, and P. Bjorntorp Estrogen Replacement Therapy Decreases Hyperandrogenicity and Improves Glucose Homeostasis and Plasma Lipids in Postmenopausal Women With Noninsulin-Dependent Diabetes Mellitus J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 638 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Franks Polycystic Ovary Syndrome N. Engl. J. Med., September 28, 1995; 333(13): 853 - 861. [Full Text] [PDF]
|
|
|
|
|
|
E. D. Schriock, C. K. Buffington, J. R. Givens, and J. E. Buster Enhanced Post-Receptor Insulin Effects in Women Following Dehydroepiandrosterone Infusion Reproductive Sciences, January 1, 1994; 1(1): 74 - 78. [Abstract] [PDF]
|
|
|
|
 |
|
 M. BERGMAN, C. MIGAKE, and P. FELIG Misdiagnosis of Gestational Diabetes and Hypoglycemia Using Portable Blood Glucose Meters Arch Intern Med, November 1, 1989; 149(11): 2602 - 2603. [Abstract] [PDF]
|
|
|
|
|
|
R. S. RITTMASTER and D. L. LORIAUX Hirsutism Ann Intern Med, January 1, 1987; 106(1): 95 - 107. [Abstract] [PDF]
|
|
|
|
|
|
S. I. TAYLOR, R. F. DONS, E. HERNANDEZ, J. ROTH, and P. GORDEN Insulin Resistance Associated with Androgen Excess in Women with Autoantibodies to the Insulin Receptor Ann Intern Med, December 1, 1982; 97(6): 851 - 855. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
