| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 49, 905-916, Copyright © 1979 by Endocrine Society
ARTICLES |
PC MacDonald, JD Madden, PF Brenner, JD Wilson and PK Siiteri
The purpose of this study was to quantify the various sources of estrone (E1) and 17 beta-estradiol (E2) production in normal men and in women with testicular feminization. The mean production rate of E1 in four young adult men was 58 micrograms/24 h, while that of E2 was 44 micrograms/24 h. In these men, E1 production could be accounted for totally by extraglandular formation through 1) aromatization of plasma androstenedione, 2) conversion of E2 which was formed from the aromatization of plasma testosterone, and 3) conversion of secreted E2. In these men, only 12 micrograms or less of E2 production could not be accounted for by extraglandular formation from plasma C19 precursors, and is presumed to have arisen by testicular secretion. In six women with testicular feminization, the mean production rate of E1 was 99 micrograms/24 h, while that of E2 was 77 micrograms/24 h. THe amount of E2 production that arose by glandular secretion could be computed in four of these women and was considerably greater than that found in the young adult men. In these women with testicular feminization, an average of 44 micrograms/24 h E2 could not be accounted for by extraglandular formation and is presumed to have arisen by testicular secretion. The mean plasma production rate of testosterone in the normal men was 5.7 mg/24 h, while that in the women with testicular feminization was 8.3 mg/24 h. However, the range of plasma production rates of testosterone in the women with testicular feminization was large (1.3--17.0 mg/24 h).
This article has been cited by other articles:
 |
|
 |
|
  M. Demura, R. M. Martin, M. Shozu, S. Sebastian, K. Takayama, W.-T. Hsu, R. A. Schultz, K. Neely, M. Bryant, B. B. Mendonca, et al. Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene Hum. Mol. Genet., November 1, 2007; 16(21): 2529 - 2541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Nielsen, C. Hagen, K. Wraae, K. Brixen, P. H. Petersen, E. Haug, R. Larsen, and M. Andersen Visceral and Subcutaneous Adipose Tissue Assessed by Magnetic Resonance Imaging in Relation to Circulating Androgens, Sex Hormone-Binding Globulin, and Luteinizing Hormone in Young Men J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2696 - 2705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. V. Dimitrov, P. Colucci, and S. Nagpal Some Aspects of the Endocrine Profile and Management of Hormone-Dependent Male Breast Cancer Oncologist, July 1, 2007; 12(7): 798 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Ohnemus, M. Uenalan, J. Inzunza, J.-A. Gustafsson, and R. Paus The Hair Follicle as an Estrogen Target and Source Endocr. Rev., October 1, 2006; 27(6): 677 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Attar and S.E. Bulun Aromatase and other steroidogenic genes in endometriosis: translational aspects Hum. Reprod. Update, January 1, 2006; 12(1): 49 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Bulun, Z. Lin, G. Imir, S. Amin, M. Demura, B. Yilmaz, R. Martin, H. Utsunomiya, S. Thung, B. Gurates, et al. Regulation of Aromatase Expression in Estrogen-Responsive Breast and Uterine Disease: From Bench to Treatment Pharmacol. Rev., September 1, 2005; 57(3): 359 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. de Ronde, A. Hofman, H. A P Pols, and F. H de Jong A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women Eur. J. Endocrinol., February 1, 2005; 152(2): 261 - 268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Binder, D. I. Iliev, A. Dufke, M. Wabitsch, R. Schweizer, M. B. Ranke, and M. Schmidt Dominant Transmission of Prepubertal Gynecomastia Due to Serum Estrone Excess: Hormonal, Biochemical, and Genetic Analysis in a Large Kindred J. Clin. Endocrinol. Metab., January 1, 2005; 90(1): 484 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Van Pottelbergh, S. Goemaere, H. Zmierczak, and J. M. Kaufman Perturbed Sex Steroid Status in Men with Idiopathic Osteoporosis and Their Sons J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4949 - 4953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Muir, G. Romalo, L. Wolf, W. Elger, and H.-U. Schweikert Estrone Sulfate Is a Major Source of Local Estrogen Formation in Human Bone J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4685 - 4692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kimura, K. Sudhir, M. Jones, E. Simpson, A.-M. Jefferis, and J. P.F. Chin-Dusting Impaired Acetylcholine-Induced Release of Nitric Oxide in the Aorta of Male Aromatase-Knockout Mice: Regulation of Nitric Oxide Production by Endogenous Sex Hormones in Males Circ. Res., December 12, 2003; 93(12): 1267 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lew, P. Komesaroff, M. Williams, T. Dawood, and K. Sudhir Endogenous Estrogens Influence Endothelial Function in Young Men Circ. Res., November 28, 2003; 93(11): 1127 - 1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. S. Melo, B. B. Mendonca, A. E. C. Billerbeck, E. M. F. Costa, M. Inacio, F. A. Q. Silva, A. M. O. Leal, A. C. Latronico, and I. J. P. Arnhold Clinical, Hormonal, Behavioral, and Genetic Characteristics of Androgen Insensitivity Syndrome in a Brazilian Cohort: Five Novel Mutations in the Androgen Receptor Gene J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3241 - 3250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Z. Leder, K. M. LeBlanc, D. A. Schoenfeld, R. Eastell, and J. S. Finkelstein Differential Effects of Androgens and Estrogens on Bone Turnover in Normal Men J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 204 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Issa, D. Schnabel, M. Feix, L. Wolf, H.-E. Schaefer, D. W. Russell, and H.-U. Schweikert Human Osteoblast-Like Cells Express Predominantly Steroid 5{alpha}-Reductase Type 1 J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5401 - 5407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Komesaroff, M. Fullerton, M. D. Esler, A. Dart, G. Jennings, and K. Sudhir Low-Dose Estrogen Supplementation Improves Vascular Function in Hypogonadal Men Hypertension, November 1, 2001; 38(5): 1011 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. P. Ly, M. Jimenez, T. N. Zhuang, D. S. Celermajer, A. J. Conway, and D. J. Handelsman A Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4078 - 4088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Smith, S. Bennett, L. M. Evans, H. G. Kynaston, M. Parmar, M. D. Mason, J. R. Cockcroft, M. F. Scanlon, and J. S. Davies The Effects of Induced Hypogonadism on Arterial Stiffness, Body Composition, and Metabolic Parameters in Males with Prostate Cancer J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4261 - 4267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nagata, N. Takatsuka, H. Shimizu, H. Hayashi, T. Akamatsu, and K. Murase Effect of Soymilk Consumption on Serum Estrogen and Androgen Concentrations in Japanese Men Cancer Epidemiol. Biomarkers Prev., March 1, 2001; 10(3): 179 - 184. [Abstract] [Full Text]
|
|
|
|
|
|
A. W. van den Beld, F. H. de Jong, D. E. Grobbee, H. A. P. Pols, and S. W. J. Lamberts Measures of Bioavailable Serum Testosterone and Estradiol and Their Relationships with Muscle Strength, Bone Density, and Body Composition in Elderly Men J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3276 - 3282. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. J. Hayes and J. H. Eichhorn Case 12-2000- A 60-Year-Old Man with Persistent Gynecomastia after Excision of a Pituitary Adenoma N. Engl. J. Med., April 20, 2000; 342(16): 1196 - 1204. [Full Text] [PDF]
|
|
|
|
|
|
R. Marcus, D. Leary, D. L. Schneider, E. Shane, M. Favus, and C. A. Quigley The Contribution of Testosterone to Skeletal Development and Maintenance: Lessons from the Androgen Insensitivity Syndrome J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1032 - 1037. [Abstract] [Full Text]
|
|
|
|
|
|
B. B. Rasmussen, E. Volpi, D. C. Gore, and R. R. Wolfe Androstenedione Does Not Stimulate Muscle Protein Anabolism in Young Healthy Men J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 55 - 59. [Abstract] [Full Text]
|
|
|
|
|
|
Estrogen: Consequences and Implications of Human Mutations in Synthesis and Action J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4677 - 4694. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Wilson The Role of Androgens in Male Gender Role Behavior Endocr. Rev., October 1, 1999; 20(5): 726 - 737. [Abstract] [Full Text]
|
|
|
|
|
|
K. Sudhir and P. A. Komesaroff Cardiovascular Actions of Estrogens in Men J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3411 - 3415. [Full Text] [PDF]
|
|
|
|
|
|
A. P. Cemeroglu, A. L. Barkan, G. B. Kletter, I. Z. Beitins, and C. M. Foster Changes in Serum Immunoreactive and Bioactive Growth Hormone Concentrations in Boys with Advancing Puberty and in Response to a 20-Hour Estradiol Infusion J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2166 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R. Agarwal, C. I. Ashanullah, E. R. Simpson, and S. E. Bulun Alternatively Spliced Transcripts of the Aromatase Cytochrome P450 (CYP19) Gene in Adipose Tissue of Women J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 70 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhao, J. E. Nichols, S. E. Bulun, C. R. Mendelson, and E. R. Simpson Aromatase P450 Gene Expression in Human Adipose Tissue J. Biol. Chem., July 7, 1995; 270(27): 16449 - 16457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Smith, J. Boyd, G. R. Frank, H. Takahashi, R. M. Cohen, B. Specker, T. C. Williams, D. B. Lubahn, and K. S. Korach Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man N. Engl. J. Med., October 20, 1994; 331(16): 1056 - 1061. [Abstract] [Full Text]
|
|
|
|
|
|
G. D. Braunstein Gynecomastia N. Engl. J. Med., February 18, 1993; 328(7): 490 - 495. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
