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Journal of Clinical Endocrinology & Metabolism, Vol 49, 658-660, Copyright © 1979 by Endocrine Society

ARTICLES

The role of thyronine in thyroid hormone metabolism

P Willetts, DN Crossley, DB Ramsden and R Hoffenberg

Thryonine (T0) has been identified in human urine using gas chromatography-mass fragmentography (G.C.M.F.). In 22 normal individuals urinary T0 concentration was found to range between 8--25 nmol/24h. Assuming the mean normal thyroxine (T4) production rate to be approximately 100 nmol/24h, our findings indicate that less than 20% of this could be accounted for as urinary T0 excretion, thus supporting earlier findings that the peripheral metabolism of T4 is not limited solely to deiodination.




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Copyright © 1979 by The Endocrine Society