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Journal of Clinical Endocrinology & Metabolism, Vol 49, 652-654, Copyright © 1979 by Endocrine Society

ARTICLES

Pulsatile subcutaneous nocturnal administration of GnRH by portable infusion pump in hypogonadotropic hypogonadism: initiation of gonadotropin responsiveness

RI Jacobson, LE Seyler Jr, WV Tamborlane Jr, JM Gertner and M Genel

GnRH was administered subcutaneously in hourly pulses for 10 consecutive nights to two immature males with Kallmann's Syndrome using a portable, battery-operated infusion pump adapted for home use. Pulsatile GnRH produced a progressive increase in urinary gonadotropin excretion, a significant increase in mean basal plasma FSH, pulsatile LH release, and an increased LH response to a standard 3 hour GnRH infusion test. One subject developed a striking increment in plasma testosterone in response to GnRH pulses, as well as a biphasic LH response to the 3 hour infusion.




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Copyright © 1979 by The Endocrine Society