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Journal of Clinical Endocrinology & Metabolism, Vol 49, 649-651, Copyright © 1979 by Endocrine Society

ARTICLES

beta-Endorphin in the human pancreas

JF Bruni, WB Watkins and SS Yen

Using a specific antiserum, beta-endorphin was quantitated in 8 human pancreas obtained at autopsy by radioimmunoassay and localized by immunocytochemistry. The mean (+/- SE) concentration of beta-endorphin in pancreatic extracts of 5 non-diabetic adults was 13.5 +/- 9.8 ng/gm with a range of 2.1 to 52.8 ng/gm of tissue. Pancreatic beta-endorphin concentration in two premature infants were within the range found in adults. In one diabetic pancreas, there was no measurable beta- endorphin. Specific beta-endorphin immunofluorescence is localized within the pancreatic islets. This finding suggests that beta-endorphin may participate in intraislet regulation of pancreatic hormone secretion.


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S. Risch, R. Cohen, D. Janowsky, N. Kalin, and D. Murphy
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N. Kalin, S. Risch, R. Cohen, T Insel, and D. Murphy
Dexamethasone fails to suppress beta-endorphin plasma concentrations in humans and rhesus monkeys
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