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*CALCITONIN, SALMON
*POTASSIUM
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*Paget's Disease of Bone

Journal of Clinical Endocrinology & Metabolism, Vol 49, 635-637, Copyright © 1979 by Endocrine Society

ARTICLES

Effect of acute administration of salmon and human calcitonin on blood urate and renal excretion of uric acid in patients with Paget's disease of bone

A Gattereau, P Vinay, P Bielmann, J Davignon, G Lemieux and A Gougoux

The sc injection of salmon calcitonin (CT) (100 MRC U) or human CT (50 MRC U) to Pagetic patients reduces the plasma urate concentration and increases the renal excretion of uric acid. This effect is independent of the natriuretic, phosphaturic, or glycosuric actions of CT and is not due to the transient increment of the glomerular filtration rate noted after CT administration. Our results suggest that the hypouricemia observed during CT treatment is related, at least in part to a direct action on the renal handling of uric acid.




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