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Journal of Clinical Endocrinology & Metabolism, Vol 49, 475-477, Copyright © 1979 by Endocrine Society

ARTICLES

ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of beta-LPH conversion to beta- endorphin

T Suda, Y Abe, H Demura, R Demura, K Shizume, N Tamahashi and N Sasano

ACTH, beta-lipotropin (beta-LPH) and beta-endorphin concentrations were determined in pituitary adenomas of the patients with Cushing's disease. Immunoreactive ACTH and beta-endorphin were present in high concentrations and essentially equimolar amounts in pituitary adenomas. beta-LPH conversion to beta-endorphin was activated in pituitaries associated with ACTH/beta-LPH producing adenomas. Immunoreactive ACTH and beta-endorphin concentrations were markedly suppressed in the surrounding tissues.


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S. Risch, N. Kalin, D. Janowsky, R. Cohen, D Pickar, and D. Murphy
Co-release of ACTH and beta-endorphin immunoreactivity in human subjects in response to central cholinergic stimulation
Science, October 7, 1983; 222(4619): 77 - 77.
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