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Journal of Clinical Endocrinology & Metabolism, Vol 49, 387-390, Copyright © 1979 by Endocrine Society

ARTICLES

Short term growth in boys with delayed puberty after diagnostic human chorionic gonadotropin administration

JS van den Bosch, AG Smals, PW Kloppenborg and IM Valk

Using a sensitive measuring device, 3-day hCG administration (Pregnyl; 1500 IU daily) was shown to temporarily increase ulnar growth velocity from prepubertal (0.40 +/- 0.35 mm/3 weeks to pubertal values (1.1 +/- 0.64 mm/3 weeks) in 10 boys with delayed puberty. This growth-promoting effect of diagnostic hCG administration, which was demonstrable for 3-- 9 weeks, was associated with an overt rise in plasma testosterone from 129 +/- 126 to 818 +/- 419 ng/100 ml and an approximate doubling of the serum alkaline phosphatase activities from 193 +/- 46 to 376 +/- 115 U/liter, suggesting an initiated growth spurt.




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